LAG3
LAG-3是一種具有免疫抑制功能的跨膜蛋白，其結(jié)構(gòu)由胞外區(qū)的四個免疫球蛋白超家族結(jié)構(gòu)域、跨膜區(qū)和胞內(nèi)區(qū)的絲氨酸磷酸化位點(diǎn)等關(guān)鍵元件組成。功能上，LAG-3主要通過與配體如MHC II、半乳糖凝集素-3等的相互作用，抑制T細(xì)胞的激活和細(xì)胞因子分泌，從而維持免疫穩(wěn)態(tài)。在信號通路方面，LAG-3與其配體結(jié)合后，通過胞內(nèi)結(jié)構(gòu)域與下游信號分子的相互作用，調(diào)節(jié)T細(xì)胞的活化狀態(tài)。在腫瘤治療中，LAG-3作為重要靶點(diǎn)，通過阻斷或抑制LAG-3可增強(qiáng)T細(xì)胞對腫瘤的殺傷作用。因此，深入研究LAG-3的結(jié)構(gòu)、功能和信號通路，對于開發(fā)新的免疫療法具有重要意義。
熱銷產(chǎn)品
Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial (Active) (CSB-MP012719HU3)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human LAG3 at 2 μg/ml can bind Anti-LAG3 recombinant antibody(CSB-RA012719MA1HU). The EC50 is 2.306-2.731 ng/mL.
LAG3 Recombinant Monoclonal Antibody (CSB-RA012719MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA012719MA1HU diluted at 1：100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
The Binding Activity of Human LAG3 with Anti-LAG3 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LAG3(CSB-MP012719HU3) at 2 μg/mL can bind Anti-LAG3 recombinant antibody. The EC50 is 2.306-2.731 ng/mL.
Human Lymphocyte activation gene 3 protein(LAG3) ELISA kit (CSB-EL012719HU)
驗(yàn)證數(shù)據(jù)
貨號：CSB-EL012719HU
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
LAG3 Antibodies
LAG3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012719GA01HU | LAG3 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA012719LA01HU | LAG3 Antibody | Human | ELISA, WB, IF |
| CSB-PA012719LC01HU | LAG3 Antibody, FITC conjugated | Human | |
| CSB-PA012719LD01HU | LAG3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005868 | LAG3 Antibody | Human | WB, ELISA |
| CSB-PA172061 | LAG3 Antibody | Human | ELISA,WB |
| CSB-MA012719A0m | LAG3 Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
| CSB-RA012719MA1HU | LAG3 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
LAG3 Proteins
LAG3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012719HU1 CSB-BP012719HU1 CSB-MP012719HU1 CSB-EP012719HU1-B |
Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012719HU1 | Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial | E.coli |
| CSB-CF012719HU | Recombinant Human Lymphocyte activation gene 3 protein (LAG3) | in vitro E.coli expression system |
LAG3 ELISA Kit
LAG3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012719HU | Human Lymphocyte activation gene 3 protein(LAG3) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
